生物医药是国际研究的热点和前沿领域，是国家战略性新兴产业。该方向是材料与医药等高新技术的多学科交叉研究，纳米黏土矿物具有天然独特的理化性质和优异的生物相容性，重点研发纳米黏土矿物用于靶向药物、抗菌、抗炎、创伤处理、智能微纳机器人等领域的新型生物医药材料，对于人类重大疾病的诊断和治疗具有前瞻性的意义。 1. 恶性肿瘤靶向诊断与治疗
针对乳腺癌、结肠癌、宫颈癌、甲状腺癌和胶质瘤等恶性肿瘤重大疾病，提出靶向药物载体材料设计的新策略。充分利用纳米黏土矿物的表界面特性，通过对黏土矿物进行结构调控，构建以纳米黏土材料为基元的新型药物递送系统，发展高性能抗肿瘤功效的纳米疗法。
2. 高性能止血材料
及时而有效地控制创伤时的出血是抢救生命成功的重要环节，充分挖掘高岭石等纳米黏土矿物的吸水、浓缩血小板、诱导血小板活化、激活内源性凝血的综合效应，通过结构调控及功能组装，设计出止血性能及生物相容性优异的高性能止血材料。
3. 新型抗菌材料
针对细菌感染的全球性蔓延、威胁等重大难题，研发纳米黏土矿物的生物功能化组装新方法新技术，研制高效、稳定、普适的新型抗菌材料，从原子分子尺度揭示矿物与细菌的相互作用机制，为有效降低细菌感染风险提供关键技术。
针对溃疡性结肠炎治疗的难题，研究天然黏土矿物对UC治疗效果的影响及促进肠道菌群平衡的生物机制，通过黏土矿物的多功能调控与设计，以期研发工艺简单、条件温和、友好的新型抗炎材料，为肠道炎症的高效治疗提供新思路。
微纳机器人与生物医学交叉领域的研究相当活跃（Adv. Mater., 2021, 33, 2002047; IEEE T BIO-MED ENG, 2021, 68, 130-147）。本方向正在利用黏土矿物优异的理化性质和生物医药前沿开展新型微纳机器人的设计，探索其在药物或基因载体靶向、肿瘤及炎症诊疗、组织工程与再生医学等领域的应用，逐步拓展在手术机器人及其临床应用，开拓基于纳米黏土的新型微纳机器人多学科交叉特色方向。
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代表性论文：
[1] Yinin Qian, Huaming Yang*, Computational insight into the bioapplication of 2D materials: A review, Nano Today, 2023, 33, 2209883
[2] Ying Feng, Miao An, Yang Liu, Muhammad Tariq Sarwar, Huaming Yang*, Advances in chemically powered micro/nanorobots for biological applications: A review, Advanced Functional Materials, 2023, 33, 2209883
[3] Mei Long, Yi Zhang, Peng Huang, Shi Chang, Yuehua Hu, Qian Yang, Linfeng Mao, Huaming Yang*, Emerging nanoclay composite for effective hemostasis, Advanced Functional Materials, 2018, 28, 1704452. Cover page
[4] Juan Liao, Dongyue Wang, Aidong Tang, Liangjie Fu, Jing Ouyang, Huaming Yang*, Surface modified halloysite nanotubes with different lumen diameters as drug carriers for cancer therapy, Chemical Communications, 2021, 57, 9470-9473.
[5] Mei Long, Bin Zhang, Siyu Peng, Juan Liao, Yi Zhang, Jie Wang, Mi Wang, Bo Qin, Jufang Huang, Jing Huang, Xiaoping Chen, Huaming Yang*, Interactions between two-dimensional nanoclay and blood cells in hemostasis,
Materials Science and Engineering: C, 2019, 105, 110081.
[6] Mei Long, Yi Zhang, Zhan Shu, Aidong Tang, Jing Ouyang, Huaming Yang*, Fe
2O
3 nanoparticles anchored on 2D kaolinite with enhanced antibacterial activity,
Chemical Communications, 2017, 53, 6255-6258.
[7] Hao Wang, Wenxin Bao, Muhammad Tariq Sarwar, Luyuan Tian, Aidong Tang*, Huaming Yang*, Mineral-enhanced manganese ferrite with multiple enzyme-mimicking activities for visual detection of disease marker,
Inorganic Chemistry, 2023, 62, 8418-8427
[8] Juan Liao, Hao Wang, Nian Liu*, Huaming Yang*, Functionally modified halloysite nanotubes for personalized bioapplications,
Advances in Colloid and Interface Science, 2023, 311, 102812.
[9] Yang Liu, Ying Feng, Miao An, Muhammad Tariq Sarwar, Huaming Yang*, Advances in Finite Element Analysis of External Field Driven Micro/Nanorobots: A Review,
Advanced Intelligent Systems, 2023, 5, 2200466
[10] Hao Wang, Muhammad Tariq Sarwar, Luyuan Tian, Wenxin Bao, Huaming Yang*, Nanoclay modulates cation occupancy in manganese ferrite for catalytic antibacterial treatment,
Inorganic Chemistry, 2022, 61(44), 17692-17702
